Abstract
The retinal toxicity of intraocular liposome-bound cyclosporine was studied in albino rabbits by means of electrophysiology and histopathology. During a followup period of one month, no histopathological or electroretinographic changes were noted using concentrations of 100, 200 and 500 micrograms injected intravitreally.
Publication types
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Animals
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Cyclosporins / administration & dosage
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Cyclosporins / toxicity*
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Drug Carriers
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Electrophysiology
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Injections
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Liposomes
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Rabbits
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Retina / drug effects*
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Retina / pathology
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Time Factors
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Vitreous Body / metabolism*
Substances
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Cyclosporins
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Drug Carriers
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Liposomes