Amantadine as a drug to mitigate the effects of COVID-19

Gonzalo Emiliano Aranda Abreu; María Elena Hernández Aguilar; Deissy Herrera Covarrubias; Fausto Rojas Durán

doi:10.1016/j.mehy.2020.109755

Amantadine as a drug to mitigate the effects of COVID-19

Med Hypotheses. 2020 Jul:140:109755. doi: 10.1016/j.mehy.2020.109755. Epub 2020 Apr 25.

Authors

Gonzalo Emiliano Aranda Abreu¹, María Elena Hernández Aguilar¹, Deissy Herrera Covarrubias¹, Fausto Rojas Durán¹

Affiliation

¹ Centro de Investigaciones Cerebrales/Universidad Veracruzana, Av. Luis Castelazo Ayala s/n, carr. Xalapa-Veracruz, km 3.5, C.P. 91190 Xalapa, Veracruz, Mexico.

Abstract

The SARS-CoV-2 virus has spread around the world. At this time, there is no vaccine that can help people prevent the spread of coronavirus. We are proposing amantadine as a drug that can be used to mitigate the effects of the virus. It is demonstrated by docking models how amantadine can exert its action on Coronavirus viroporin E.

Keywords: Amantadine; COVID-19; Docking; Viroporin.

MeSH terms

Amantadine / therapeutic use*
Betacoronavirus
COVID-19
COVID-19 Drug Treatment
Coronavirus Envelope Proteins
Coronavirus Infections / drug therapy*
Humans
Ion Channels / chemistry
Ion Channels / drug effects
Ligands
Molecular Docking Simulation
Pandemics
Pneumonia, Viral / drug therapy*
Protein Conformation
SARS-CoV-2
Viral Envelope Proteins / chemistry*
Viral Nonstructural Proteins / chemistry
Viral Nonstructural Proteins / drug effects
Viroporin Proteins

Substances

Coronavirus Envelope Proteins
Ion Channels
Ligands
Viral Envelope Proteins
Viral Nonstructural Proteins
Viroporin Proteins
envelope protein, SARS-CoV-2
Amantadine