Abstract
Tumor phototherapy is of great significance for the expansion and advancement of cancer treatment methods. Herein, two-dimensional boron nanosheets (B NSs) with a thickness of 2.4 nm exhibiting an excellent photothermal conversion performance were developed via a simple liquid phase ultrasonic stripping method. Following the loading of the photosensitizer agent chlorin e6 (Ce6) and subsequent modification with poly(allylamine hydrochloride) (PAH) and poly(acrylic acid) (PAA), a B@Ce6-PAH-PAA NS nanomedicine exhibiting dual modal imaging-guided cancer photothermal therapy (PTT) and photodynamic therapy (PDT) properties, as well as outstanding stability was developed. The suitable nano-size (120 nm) of B@Ce6-PAH-PAA NSs can allow drugs to target tumor tissue with an enhanced permeability and retention effect (EPR). The cytotoxicity experiments demonstrated that B@Ce6-PAH-PAA NSs exhibited good biocompatibility even at high concentrations. Furthermore, the in vitro and in vivo experiments showed the excellent synergistic therapeutic effect of this nanomedicine for PTT and PDT.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Acrylic Resins / chemistry
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Acrylic Resins / pharmacology
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Animals
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Antineoplastic Agents / chemical synthesis
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Antineoplastic Agents / chemistry
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Antineoplastic Agents / pharmacology*
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Biocompatible Materials / chemical synthesis
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Biocompatible Materials / chemistry
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Biocompatible Materials / pharmacology*
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Boron / chemistry
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Boron / pharmacology
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Cell Proliferation / drug effects
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Cell Survival / drug effects
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Chlorophyllides
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Drug Screening Assays, Antitumor
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Female
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Humans
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MCF-7 Cells
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Mammary Neoplasms, Experimental / drug therapy
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Mammary Neoplasms, Experimental / metabolism
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Mammary Neoplasms, Experimental / pathology
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Mice
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Mice, Inbred BALB C
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Mice, Nude
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Nanoparticles / chemistry
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Particle Size
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Photochemotherapy*
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Photosensitizing Agents / chemical synthesis
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Photosensitizing Agents / chemistry
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Photosensitizing Agents / pharmacology*
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Polyamines / chemistry
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Polyamines / pharmacology
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Porphyrins / chemistry
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Porphyrins / pharmacology
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Surface Properties
Substances
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Acrylic Resins
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Antineoplastic Agents
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Biocompatible Materials
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Chlorophyllides
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Photosensitizing Agents
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Polyamines
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Porphyrins
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polyallylamine
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carbopol 940
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phytochlorin
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Boron