Blood microparticles are a component of immune modulation in red blood cell transfusion

Marion Klea Pinheiro; Marie Tamagne; Rahma Elayeb; Muriel Andrieu; France Pirenne; Benoît Vingert

doi:10.1002/eji.201948481

Blood microparticles are a component of immune modulation in red blood cell transfusion

Eur J Immunol. 2020 Aug;50(8):1237-1240. doi: 10.1002/eji.201948481. Epub 2020 Jun 2.

Authors

Marion Klea Pinheiro^{1

2

3

4}, Marie Tamagne^{1

2

3

4}, Rahma Elayeb^{1

2

3

4}, Muriel Andrieu⁵, France Pirenne^{1

2

3

4}, Benoît Vingert^{1

2

3

4}

Affiliations

¹ Etablissement Français du Sang, Ile-de-France, France.
² Institut Mondor de Recherche Biomédicale, lnserm U955, Equipe Pirenne, Créteil, France.
³ Laboratory of Excellence GR-Ex, Paris, France.
⁴ Université Paris-Est, Créteil, France.
⁵ Institute Cochin, Cochin Cytometry and Immunobiology Facility, Paris, France.

PMID: 32379351
DOI: 10.1002/eji.201948481

Abstract

Patients may display alloimmunization following transfusion. Microparticles (MPs) released into the blood are present in transfusion products. We show that MPs can modulate the immune system, CD4⁺ T-cell, and humoral responses, through their concentration, cellular origin and phenotype, and should therefore be considered to reduce the immune impact of transfusion.

Keywords: Alloimmunization; Blood extracellular vesicles; CD4+ T-cell response.

Publication types

Letter
Research Support, Non-U.S. Gov't

MeSH terms

Animals
Cell-Derived Microparticles / physiology*
Cytokines / physiology
Erythrocyte Transfusion*
Erythrocytes / immunology*
Humans
Immunomodulation*
Mice

Substances

Cytokines