Epigenetic and functional changes imposed by NUP98-HOXA9 in a genetically engineered model of chronic myeloid leukemia progression

Ivan Sloma; Philip Beer; Christophe Desterke; Elizabeth Bulaeva; Misha Bilenky; Annaïck Carles; Michelle Moksa; Kamini Raghuram; Cedric Brimacombe; Karen Lambie; Ali G Turhan; Orianne Wagner-Ballon; Philippe Gaulard; Keith Humphries; Martin Hirst; Connie J Eaves

doi:10.3324/haematol.2020.249243

Epigenetic and functional changes imposed by NUP98-HOXA9 in a genetically engineered model of chronic myeloid leukemia progression

Haematologica. 2021 Mar 1;106(3):881-885. doi: 10.3324/haematol.2020.249243.

Authors

Ivan Sloma^{1

2}, Philip Beer¹, Christophe Desterke³, Elizabeth Bulaeva¹, Misha Bilenky⁴, Annaïck Carles⁵, Michelle Moksa⁵, Kamini Raghuram¹, Cedric Brimacombe¹, Karen Lambie¹, Ali G Turhan⁶, Orianne Wagner-Ballon^{7

2}, Philippe Gaulard^{7

8}, Keith Humphries¹, Martin Hirst^{4

5}, Connie J Eaves^{1

9}

Affiliations

¹ Terry Fox Laboratory, British Columbia Cancer Agency, Vancouver, British Columbia, Canada
² Assistance Publique des Hôpitaux de Paris (AP-HP), Hopital Henri Mondor, Departement d’Hematologie et Immunologie, Creteil, France
³ Université Paris-Sud, Faculté de Médecine Kremlin Bicêtre, INSERM UMS 33 Villejuif, France
⁴ Canada’s Michael Smith Genome Sciences Centre, British Columbia Cancer Agency, Vancouver, British Columbia, Canada
⁵ Department of Microbiology and Immunology, Michael Smith Laboratories, University of British Columbia, Vancouver, British Columbia, Canada
⁶ Service d’Hématologie Biologique, Hôpital Universitaire Paris-Saclay, INSERM U935, AP-HP, Kremlin Bicêtre, France
⁷ Université Paris Est Creteil, INSERM, IMRB, Creteil, France
⁸ INSERM UMRS955, Pathology Department, Hôpital Henri Mondor, AP-HP, Faculté de Médecine de Créteil, Université Paris-Est Créteil, Créteil, France
⁹ University of British Columbia, Department of Medical Genetics, Vancouver, British Columbia, Canada

No abstract available

Publication types

Letter

MeSH terms

Epigenesis, Genetic
Homeodomain Proteins / genetics
Humans
Leukemia, Myelogenous, Chronic, BCR-ABL Positive* / genetics
Leukemia, Myeloid* / genetics
Nuclear Pore Complex Proteins / genetics
Oncogene Proteins, Fusion / genetics
Translocation, Genetic

Substances

Homeodomain Proteins
Nuclear Pore Complex Proteins
Nup98 protein, human
Oncogene Proteins, Fusion
nuclear pore complex protein 98

Grants and funding

Funding: IS received a grant from Cent pour Sang La Vie and AGT received a grant from the Oncostem program of the French national IPSC Infrastructure “Investissements d’Avenir” INGESTEM. CE received grants supported by funds from the Terry Fox Run and from CIHR. MH received grants supported by funds from the Terry Fox Run and the Terry Fox Research Institute (TFF-122869).