Clinical features of familial clustering in patients infected with 2019 novel coronavirus in Wuhan, China

Jinzhong Li; Xiaobing Gong; Zhigang Wang; Renzhou Chen; Taoyuan Li; Dongyu Zeng; Minran Li

doi:10.1016/j.virusres.2020.198043

Clinical features of familial clustering in patients infected with 2019 novel coronavirus in Wuhan, China

Virus Res. 2020 Sep:286:198043. doi: 10.1016/j.virusres.2020.198043. Epub 2020 Jun 2.

Authors

Jinzhong Li¹, Xiaobing Gong¹, Zhigang Wang², Renzhou Chen³, Taoyuan Li¹, Dongyu Zeng¹, Minran Li⁴

Affiliations

¹ Departments of Infectious Disease, The First Affiliated Hospital of Jinan University, Guangzhou, Guangdong 510630, PR China.
² Departments of Intensive Care Unit, The First Affiliated Hospital of Jinan University, Guangzhou, Guangdong 510630, PR China.
³ Department of General Surgery, Hankou Hospital of Wuhan City, Wuhan 430312, Hubei Province, China.
⁴ Departments of Infectious Disease, The First Affiliated Hospital of Jinan University, Guangzhou, Guangdong 510630, PR China. Electronic address: muziran@126.com.

Abstract

An epidemic caused by SARS-Coronavirus-2 (SARS-CoV-2) infection has appeared in Wuhan City in December 2019. The disease has shown a "clustering epidemic" pattern, and family-clustered onset has been the main characteristic. We collected data about 130 cases from 35 cluster-onset families (COFs) and 41 cases from 16 solitary-onset families (SOFs). The incidence of 2019 coronavirus disease (COVID-19) in COFs was significantly higher than that of SOFs. Our study also showed that patients with exposure to high-risk factors (respiratory droplets and close contact), advanced age, and comorbidities were more likely to develop COVID-19 in the COFs. In addition, advanced age and elevated neutrophil/lymphocyte ratio (NLR) were risk factors for death in patients with SARS-CoV-2 infection in the COFs.

Keywords: 2019 Coronavirus disease; Cluster-onset families; SARS-Coronavirus-2; Solitary-onset families.

MeSH terms

Adult
Age Factors
Aged
Aged, 80 and over
Betacoronavirus / pathogenicity*
Betacoronavirus / physiology
COVID-19
China
Cluster Analysis
Comorbidity
Coronary Disease / diagnosis
Coronary Disease / mortality
Coronary Disease / physiopathology*
Coronavirus Infections / diagnosis
Coronavirus Infections / mortality
Coronavirus Infections / physiopathology*
Coronavirus Infections / transmission*
Diabetes Mellitus / diagnosis
Diabetes Mellitus / mortality
Diabetes Mellitus / physiopathology*
Female
Hospitalization
Humans
Hypertension / diagnosis
Hypertension / mortality
Hypertension / physiopathology*
Leukocyte Count
Lymphocytes / pathology
Lymphocytes / virology
Male
Middle Aged
Neutrophils / pathology
Neutrophils / virology
Pandemics
Pneumonia, Viral / diagnosis
Pneumonia, Viral / mortality
Pneumonia, Viral / physiopathology*
Pneumonia, Viral / transmission*
Retrospective Studies
Risk Factors
SARS-CoV-2
Severity of Illness Index
Survival Analysis