Marine microbial alkaline protease: An efficient and essential tool for various industrial applications

Int J Biol Macromol. 2020 Oct 15:161:1216-1229. doi: 10.1016/j.ijbiomac.2020.06.072. Epub 2020 Jun 10.

Abstract

With the modern world focusing on environmental friendly products, more and more chemical processes are being replaced by enzymatic methods. Alkaline proteases (APases) place more than 50% of the total world enzyme production. Marine microorganisms are capable of producing an extensive spectrum of APases which have important ecological roles and promising industrial applications. Marine microbial APases can meet the required market demand for various industrial processes due to their strong specificity, mild reaction conditions, environmental friendliness and easy inactivation or control in comparison with chemical catalysts. In this review, a bird's-eye view on recent research works in the field of APase production from marine microorganisms as well as their potential industrial applications. The effect of various physical and chemical parameters on marine microbial APase is discussed. Isolation, purification, optimum pH and temperature of marine microbial APases are also reported. We anticipate that this review will provide an outline of potential industrial application of marine microbial APases and open new avenues to help the academicians, researchers and industrialists.

Keywords: Alkaline proteases; Biochemical properties; Industrial applications; Marine microorganisms.

Publication types

  • Review

MeSH terms

  • Aquatic Organisms / enzymology*
  • Bacterial Proteins / biosynthesis
  • Bacterial Proteins / chemistry
  • Bacterial Proteins / isolation & purification
  • Bacterial Proteins / metabolism*
  • Biotechnology
  • Chemical Phenomena
  • Drug Discovery
  • Endopeptidases / biosynthesis
  • Endopeptidases / chemistry
  • Endopeptidases / isolation & purification
  • Endopeptidases / metabolism*
  • Enzyme Activation / drug effects
  • Hydrogen-Ion Concentration
  • Industry
  • Kinetics
  • Metals / chemistry
  • Protease Inhibitors / chemistry
  • Protease Inhibitors / pharmacology
  • Substrate Specificity
  • Temperature

Substances

  • Bacterial Proteins
  • Metals
  • Protease Inhibitors
  • Endopeptidases
  • alkaline protease