Composite materials based on chitosan/gold nanoparticles: From synthesis to biomedical applications

Ana B da Silva; Késsily B Rufato; Ariel C de Oliveira; Paulo R Souza; Elisângela P da Silva; Edvani C Muniz; Bruno H Vilsinski; Alessandro F Martins

doi:10.1016/j.ijbiomac.2020.06.113

Composite materials based on chitosan/gold nanoparticles: From synthesis to biomedical applications

Int J Biol Macromol. 2020 Oct 15:161:977-998. doi: 10.1016/j.ijbiomac.2020.06.113. Epub 2020 Jun 15.

Authors

Ana B da Silva¹, Késsily B Rufato¹, Ariel C de Oliveira¹, Paulo R Souza², Elisângela P da Silva², Edvani C Muniz³, Bruno H Vilsinski², Alessandro F Martins⁴

Affiliations

¹ Laboratory of Materials, Macromolecules, and Composites (LaMMAC), Federal University of Technology, Apucarana 86812-460, Brazil; Group of Polymers and Composite Materials (GMPC), Chemical Department, State University of Maringá (UEM), Maringá 87020-900, Brazil.
² Group of Polymers and Composite Materials (GMPC), Chemical Department, State University of Maringá (UEM), Maringá 87020-900, Brazil.
³ Group of Polymers and Composite Materials (GMPC), Chemical Department, State University of Maringá (UEM), Maringá 87020-900, Brazil; Department of Chemistry, Federal University of Piauí (UFPI), 64049-550 Teresina, Brazil.
⁴ Laboratory of Materials, Macromolecules, and Composites (LaMMAC), Federal University of Technology, Apucarana 86812-460, Brazil; Group of Polymers and Composite Materials (GMPC), Chemical Department, State University of Maringá (UEM), Maringá 87020-900, Brazil; Department of Chemical and Biological Engineering, Colorado State University (CSU), Fort Collins 80523, USA. Electronic address: afmartins@utfpr.edu.br.

PMID: 32553969
DOI: 10.1016/j.ijbiomac.2020.06.113

Abstract

Conventional strategies (Turkevich's, and modified Turkevich's methods) often synthesize gold nanoparticles (AuNPs). These pathways produce AuNPs using toxic chemistries to reduce Au(III) and stabilize Au(0) atoms upon the AuNP surfaces. To overcome the disadvantages of conventional approaches, chitosan and chitosan-based materials associate with Au(III) to produce composites. Chitosan and derivatives reduce Au(III) and stabilize AuNPs, promoting biocompatibility to the composites, following approaches in-situ. In this review, we report methods to develop chitosan/AuNPs-based composites. The main criticism is about the mechanism of composite formation. Also, we highlight applications of chitosan/AuNPs-based devices in the biomedical arena. We report the synthesis of biosensors, drug delivery devices, scaffolds, antimicrobial coatings, and others. The major criticism is concerning the material design and the lack of data regarding the composite biocompatibility. We support a critical viewpoint.

Keywords: Biosensors; Hydrogels; Polyelectrolyte complexes.

Publication types

Review

MeSH terms

Animals
Biocompatible Materials / chemistry*
Biomedical Research / methods
Chitosan / chemistry*
Gold / chemistry*
Humans
Metal Nanoparticles / chemistry*

Substances

Biocompatible Materials
Gold
Chitosan