Dynamics of SARS-CoV-2 RT-PCR positivity and seroprevalence among high-risk healthcare workers and hospital staff

J Hosp Infect. 2020 Sep;106(1):102-106. doi: 10.1016/j.jhin.2020.06.028. Epub 2020 Jun 25.

Abstract

Staff working in units that were highly exposed to coronavirus disease 2019 were invited to participate in a 6-month study on the carriage and seroprevalence of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). The results from visits on Day 1 and Day 15 show that 41 cases of SARS-CoV-2 infection were confirmed by reverse transcriptase polymerase chain reaction and/or serology in 326 participants (overall infection rate 12.6%). The presence of comorbidities or symptoms at the time of sample collection was a risk factor for infection, but working as a physician/nurse was not a risk factor. Universal screening in high-risk units, irrespective of symptoms, allowed the identification of asymptomatic and potentially contagious infected workers, enabling them to self-isolate for 7 days.

Keywords: Antibodies; Asymptomatic; COVID-19 units; Carriage; Hospital staff.

MeSH terms

  • Adult
  • Asymptomatic Diseases*
  • Belgium
  • Betacoronavirus / immunology
  • COVID-19
  • Coronavirus Infections / immunology*
  • Diagnostic Tests, Routine / standards*
  • Diagnostic Tests, Routine / statistics & numerical data*
  • Female
  • Humans
  • Male
  • Middle Aged
  • Pandemics
  • Personnel, Hospital / statistics & numerical data*
  • Pneumonia, Viral / immunology*
  • Reverse Transcriptase Polymerase Chain Reaction / standards*
  • Reverse Transcriptase Polymerase Chain Reaction / statistics & numerical data*
  • Risk Assessment
  • Risk Factors
  • SARS-CoV-2
  • Seroepidemiologic Studies