Abstract
A supramolecular nanoprodrug based on the host-guest complexation of water-soluble pillar[5]arene (WP5) and a boronate ester linked curcumin (Cur) was constructed, which had dual-responsiveness towards pH and GSH, allowing the drug to be selectively released in hepatoma cells. In vitro studies revealed that the Dox-loaded WP5G-Cur nanoprodrug achieved co-delivery of Dox/Cur. The anti-cancer efficiency could be enhanced through synergistic chemotherapies of Dox/Cur.
MeSH terms
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Boronic Acids / chemistry*
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Calixarenes / chemistry*
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Curcumin / chemistry*
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Curcumin / metabolism
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Curcumin / pharmacology
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Doxorubicin / chemistry
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Doxorubicin / pharmacology
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Drug Carriers / chemistry
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Drug Synergism
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Esters / chemistry*
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Glutathione / metabolism
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Hep G2 Cells
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Humans
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Hydrogen-Ion Concentration
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Nanostructures / chemistry*
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Prodrugs / chemistry*
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Prodrugs / metabolism
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Solubility
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Water / chemistry*
Substances
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Boronic Acids
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Drug Carriers
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Esters
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Prodrugs
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pillar(5)arene
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Water
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Calixarenes
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Doxorubicin
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Glutathione
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Curcumin