Genotoxic effects of mycotoxins

Toxicon. 2020 Oct 15:185:104-113. doi: 10.1016/j.toxicon.2020.07.004. Epub 2020 Jul 10.

Abstract

Fungi produce mycotoxins in the presence of appropriate temperature, humidity, sufficient nutrients and if the density of the mushroom mass is favorable. Although all mycotoxins are of fungal origin, all toxic compounds produced by fungi are not called mycotoxins. The interest in mycotoxins first started in the 1960s, and today the interest in mycotoxin-induced diseases has increased. To date, 400 mycotoxins have been identified and the most important species producing mycotoxins belongs to Aspergillus, Penicillium, Alternaria and Fusarium genera. Mycotoxins are classified as hepatotoxins, nephrotoxins, neurotoxins, immunotoxins etc. In this review genotoxic and also other health effects of some major mycotoxin groups like Aflatoxins, Ochratoxins, Patulin, Fumonisins, Zearalenone, Trichothecenes and Ergot alkaloids were deeply analyzed.

Keywords: Aflatoxins; Ergot alkaloids; Fumonisins; Genotoxicity; Health effect; Mycotoxin; Ochratoxin A; Patulin; Trichothecene; Zearalenone.

Publication types

  • Review

MeSH terms

  • Aflatoxins / toxicity
  • Aspergillus
  • DNA Damage
  • Food Contamination
  • Food Microbiology
  • Fumonisins / toxicity
  • Fungi
  • Fusarium
  • Mutagens / toxicity*
  • Mycotoxins / toxicity*
  • Ochratoxins / analysis
  • Patulin
  • Trichothecenes / toxicity
  • Zearalenone / toxicity

Substances

  • Aflatoxins
  • Fumonisins
  • Mutagens
  • Mycotoxins
  • Ochratoxins
  • Trichothecenes
  • Zearalenone
  • Patulin