Abstract
Systemic lupus erythematosus (SLE) is a multifactorial autoimmune disease without an effective and safe treatment. Besides, macrophages are the major components of the innate immune system and play a critical role in the inflammation process in SLE. Secoiridoids from olive tree are phenolic compounds which have shown important pharmacological effects. Particularly, oleuropein (OL) has shown antioxidant, anti-inflammatory and immunomodulatory properties suggesting a potential application in a large number of inflammatory and reactive oxygen species (ROS)-mediated diseases. In addition, different studies have shown the importance of acyl derivatives of natural phenols due to their better hydrophilic/lipophilic balance.
MeSH terms
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Animals
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Anti-Inflammatory Agents / pharmacology
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Cytokines / metabolism
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Inflammasomes / metabolism*
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Iridoid Glucosides / pharmacology*
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Iridoids / pharmacology
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Lupus Erythematosus, Systemic / chemically induced*
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Lupus Erythematosus, Systemic / drug therapy*
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Lupus Erythematosus, Systemic / pathology
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Macrophages / drug effects
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Macrophages, Peritoneal / drug effects*
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Mice
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Mice, Inbred BALB C
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NLR Family, Pyrin Domain-Containing 3 Protein / genetics
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NLR Family, Pyrin Domain-Containing 3 Protein / metabolism*
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Olea / metabolism
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Phenols
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Terpenes / adverse effects*
Substances
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Anti-Inflammatory Agents
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Cytokines
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Inflammasomes
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Iridoid Glucosides
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Iridoids
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NLR Family, Pyrin Domain-Containing 3 Protein
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Nlrp3 protein, mouse
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Phenols
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Terpenes
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pristane
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oleuropein