The Interplay Between Exercise Metabolism, Epigenetics, and Skeletal Muscle Remodeling

Exerc Sport Sci Rev. 2020 Oct;48(4):188-200. doi: 10.1249/JES.0000000000000227.

Abstract

We explore work from within the field of skeletal muscle and across the broader field of molecular biology, to propose that the link between exercise and skeletal muscle adaptation lies in the interplay between metabolism and epigenetics. Future investigations into such an interaction are crucial to advance our understanding of the beneficial effects of exercise on performance and health.

Publication types

  • Review

MeSH terms

  • Acetyl Coenzyme A / metabolism
  • Acetylation
  • Adaptation, Physiological
  • Citric Acid Cycle
  • DNA Methylation
  • Energy Metabolism*
  • Epigenesis, Genetic*
  • Exercise / physiology*
  • Glycolysis
  • Histones / metabolism
  • Humans
  • Lipid Metabolism
  • Muscle, Skeletal / metabolism
  • Muscle, Skeletal / physiology*
  • Signal Transduction

Substances

  • Histones
  • Acetyl Coenzyme A