Free radical scavengers: An overview on heterocyclic advances and medicinal prospects

Eur J Med Chem. 2020 Oct 15:204:112607. doi: 10.1016/j.ejmech.2020.112607. Epub 2020 Jul 15.

Abstract

In the present scenario, there has been a lot of consideration toward the field of free radical chemistry. Free radicals responsive oxygen species are produced by different endogenous frameworks, exposure to various physicochemical conditions, radiation, toxins, metabolized drug by-product, and pathological states. On the off chance that free radical overpowers the body's capacity, it generates a condition known as oxidative stress, which can alter physiological conditions of the body and results in several diseases. For appropriate physiological function, it is necessary to have a proper balance between free radicals and antioxidants. Antioxidants chemically inhibit the oxidation process; they are also known as free radical scavengers. For tackling the problem of oxidative stress application of an external source of antioxidant is helpful. A lot of antioxidants of natural, semi-synthetic and synthetic origin are in use, with time search of more effective, nontoxic, safe antioxidant is intensified. The present review, discuss different synthetic derivatives bearing various heterocyclic scaffolds as radical scavengers.

Keywords: Antioxidants; Heterocycles; SAR Study; Synthetic radical scavengers.

Publication types

  • Review

MeSH terms

  • Animals
  • Drug Discovery
  • Free Radical Scavengers / chemistry*
  • Free Radical Scavengers / pharmacology*
  • Heterocyclic Compounds / chemistry*
  • Heterocyclic Compounds / pharmacology*
  • Humans

Substances

  • Free Radical Scavengers
  • Heterocyclic Compounds