Redox Regulation of STAT1 and STAT3 Signaling

Int J Mol Sci. 2020 Sep 24;21(19):7034. doi: 10.3390/ijms21197034.

Abstract

STAT1 and STAT3 are nuclear transcription factors that regulate genes involved in cell cycle, cell survival and immune response. The cross-talk between these signaling pathways determines how cells integrate the environmental signals received ultimately translating them in transcriptional regulation of specific sets of genes. Despite being activated downstream of common cytokine and growth factors, STAT1 and STAT3 play essentially antagonistic roles and the disruption of their balance directs cells from survival to apoptotic cell death or from inflammatory to anti-inflammatory responses. Different mechanisms are proposed to explain this yin-yang relationship. Considering the redox aspect of STATs proteins, this review attempts to summarize the current knowledge of redox regulation of STAT1 and STAT3 signaling focusing the attention on the post-translational modifications that affect their activity.

Keywords: STAT1; STAT3; oxidative stress; post-translational modifications.

Publication types

  • Review

MeSH terms

  • Gene Expression Regulation
  • Humans
  • Oxidation-Reduction
  • STAT1 Transcription Factor / physiology*
  • STAT3 Transcription Factor / physiology*
  • Signal Transduction*

Substances

  • STAT1 Transcription Factor
  • STAT1 protein, human
  • STAT3 Transcription Factor
  • STAT3 protein, human