Prostaglandin E₂ receptors and their role in gastrointestinal motility - Potential therapeutic targets

Prostaglandin E₂ (PGE₂) is found throughout the gastrointestinal tract in a diverse variety of functions and roles. The recent discovery of four PGE₂ receptor subtypes in intestinal muscle layers as well as in the enteric plexus has led to much interest in the study of their roles in gut motility. Gut dysmotility has been implicated in functional disease processes including irritable bowel syndrome (IBS) and slow transit constipation, and lubiprostone, a PGE₂ derivative, has recently been licensed to treat both conditions. The diversity of actions of PGE₂ in the intestinal tract is attributed to its differing effects on its downstream receptor types, as well as their varied distribution in the gut, in both health and disease. This review aims to identify the role and distribution of PGE₂ receptors in the intestinal tract, and aims to elucidate their distinct role in gut motor function, with a specific focus on functional intestinal pathologies.