HDL and cancer - causality still needs to be confirmed? Update 2020

Shiva Ganjali; Maciej Banach; Matteo Pirro; Zlatko Fras; Amirhossein Sahebkar

doi:10.1016/j.semcancer.2020.10.007

HDL and cancer - causality still needs to be confirmed? Update 2020

Semin Cancer Biol. 2021 Aug:73:169-177. doi: 10.1016/j.semcancer.2020.10.007. Epub 2020 Oct 28.

Authors

Shiva Ganjali¹, Maciej Banach², Matteo Pirro³, Zlatko Fras⁴, Amirhossein Sahebkar⁵

Affiliations

¹ Department of Medical Biotechnology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
² Department of Hypertension, WAM University Hospital in Lodz, Medical University of Lodz, Zeromskiego 113, Lodz, Poland; Polish Mother's Memorial Hospital Research Institute (PMMHRI), Lodz, Poland. Electronic address: maciejbanach77@gmail.com.
³ Unit of Internal Medicine, Department of Medicine, University of Perugia, Perugia, Italy.
⁴ Division of Medicine, Department of Vascular Medicine, Centre for Preventive Cardiology, University Medical Centre Ljubljana, Zaloška 7, 1525, Ljubljana, Slovenia; Medical Faculty, University of Ljubljana, Ljubljana, Slovenia.
⁵ Biotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran; Neurogenic Inflammation Research Center, Mashhad University of Medical Sciences, Mashhad, Iran; Halal Research Center of IRI, FDA, Tehran, Iran. Electronic address: sahebkara@mums.ac.ir.

PMID: 33130036
DOI: 10.1016/j.semcancer.2020.10.007

Abstract

An inverse correlation between high-density lipoprotein cholesterol (HDL-C) and cancer risk has been shown by several epidemiological studies. Some studies have even suggested that HDL-C can be used as a prognostic marker in patients with certain types of cancer. However, whether reduced HDL-C level is a consequential or causal factor in the development and progression of cancer remains a controversial issue. In this review, we update and summarize recent advances that highlight the role of HDL and some of its components in prognosis, diagnosis and treatment of cancer.

Keywords: Apolipoproteina; Cancer; High-density lipoprotein (HDL).

Publication types

Review

MeSH terms

Animals
Cholesterol, HDL*
Humans
Neoplasms*
Risk Factors

Substances

Cholesterol, HDL