Severe Acute Respiratory Syndrome-Coronavirus-2 (SARS-CoV-2) Antibody Responses in Children With Multisystem Inflammatory Syndrome in Children (MIS-C) and Mild and Severe Coronavirus Disease 2019 (COVID-19)

J Pediatric Infect Dis Soc. 2021 May 28;10(5):669-673. doi: 10.1093/jpids/piaa161.

Abstract

Severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) antibody responses in children remain poorly characterized. Here, we show that pediatric patients with multisystem inflammatory syndrome in children (MIS-C) possess higher SARS-CoV-2 spike immunoglobulin G (IgG) titers compared with those with severe coronavirus disease 2019, likely reflecting a longer time since the onset of infection in MIS-C patients.

Keywords: COVID-19; SARS-COV-2; antibodies; multisystem inflammatory syndrome in children (MIS-C); pediatric.

MeSH terms

  • Antibodies, Viral / immunology*
  • Antibody Formation*
  • COVID-19 / immunology*
  • COVID-19 Serological Testing
  • Child
  • Female
  • Humans
  • Immunoglobulin A / immunology
  • Immunoglobulin G / immunology
  • Immunoglobulin M / immunology
  • Male
  • SARS-CoV-2
  • Severity of Illness Index
  • Spike Glycoprotein, Coronavirus / immunology*
  • Systemic Inflammatory Response Syndrome / immunology*

Substances

  • Antibodies, Viral
  • Immunoglobulin A
  • Immunoglobulin G
  • Immunoglobulin M
  • Spike Glycoprotein, Coronavirus
  • spike protein, SARS-CoV-2

Supplementary concepts

  • pediatric multisystem inflammatory disease, COVID-19 related