Gum polysaccharide/nanometal hybrid biocomposites in cancer diagnosis and therapy

Pooyan Makvandi; Zahra Baghbantaraghdari; Wenxian Zhou; Yapei Zhang; Romila Manchanda; Tarun Agarwal; Aimin Wu; Tapas Kumar Maiti; Rajender S Varma; Bryan Ronain Smith

doi:10.1016/j.biotechadv.2021.107711

Gum polysaccharide/nanometal hybrid biocomposites in cancer diagnosis and therapy

Biotechnol Adv. 2021 May-Jun:48:107711. doi: 10.1016/j.biotechadv.2021.107711. Epub 2021 Feb 14.

Authors

Affiliations

¹ Istituto Italiano di Tecnologia, Center for Materials Interface, Pontedera 56025, Pisa, Italy. Electronic address: Pooyan.makvandi@iit.it.
² Department of Chemical, Materials & Industrial Production Engineering, University of Naples Federico II, Naples 80125, Italy.
³ Department of Orthopaedics, Zhejiang Provincial Key Laboratory of Orthopaedics, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou 325027, China.
⁴ Department of Biomedical Engineering, Institute for Quantitative Health Science & Engineering, Michigan State University, East Lansing, MI 48824, USA.
⁵ Department of Biotechnology, Indian Institute of Technology, Kharagpur 721302, India.
⁶ Regional Centre of Advanced Technologies and Materials (RCPTM), Palacky University, Olomouc, Šlechtitelů 11, 783 71, Olomouc, Czech Republic. Electronic address: Varma.Rajender@epa.gov.
⁷ Department of Biomedical Engineering, Institute for Quantitative Health Science & Engineering, Michigan State University, East Lansing, MI 48824, USA; Department of Radiology and the Molecular Imaging Program, Stanford University, Stanford, CA, 94305, USA. Electronic address: smit2901@msu.edu.

PMID: 33592279
DOI: 10.1016/j.biotechadv.2021.107711

Abstract

Biopolymers are of prime importance among which gum polysaccharides hold an eminent standing owing to their high availability and non-toxic nature. Gum biopolymers offer a greener alternative to synthetic polymers and toxic chemicals in the synthesis of metal nanostructures. Metal nanostructures accessible via eco-friendly means endow astounding characteristics to gum-based biocomposites in the field of diagnosis and therapy towards cancer diseases. In this review, assorted approaches for the assembly of nanomaterials mediated by gum biopolymers are presented and their utility in cancer diagnosis and therapy, e.g., bioimaging, radiotherapy, and phototherapy, are deliberated to provide a groundwork for future stimulative research.

Keywords: Bioimaging; Biomarkers; Cancer therapy; Gum polysaccharide nanocomposites; Metal nanoparticles; Photothermal therapy.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Humans
Nanostructures*
Neoplasms* / diagnosis
Neoplasms* / drug therapy
Phototherapy
Polymers
Polysaccharides

Substances

Polymers
Polysaccharides