Intraoperative Fluorescence-Guided Surgery in Head and Neck Squamous Cell Carcinoma

Yu-Jin Lee; Giri Krishnan; Naoki Nishio; Nynke S van den Berg; Guolan Lu; Brock A Martin; Stan van Keulen; Alexander D Colevas; Shrey Kapoor; Jonathan T C Liu; Eben L Rosenthal

doi:10.1002/lary.28822

Intraoperative Fluorescence-Guided Surgery in Head and Neck Squamous Cell Carcinoma

Laryngoscope. 2021 Mar;131(3):529-534. doi: 10.1002/lary.28822. Epub 2020 Jul 3.

Authors

Yu-Jin Lee¹, Giri Krishnan^{1

2}, Naoki Nishio¹, Nynke S van den Berg¹, Guolan Lu¹, Brock A Martin³, Stan van Keulen¹, Alexander D Colevas⁴, Shrey Kapoor¹, Jonathan T C Liu^{5

6

7}, Eben L Rosenthal^{1

8}

Affiliations

¹ Department of Otolaryngology - Head and Neck Surgery, Stanford University School of Medicine, Stanford, CA, U.S.A.
² Department of Otolaryngology, Head and Neck Surgery, University of Adelaide, Adelaide, SA, Australia.
³ Department of Pathology, Stanford University School of Medicine, Stanford, CA, U.S.A.
⁴ Department of Medicine, Division of Oncology, Stanford University School of Medicine, Stanford, CA, U.S.A.
⁵ Department of Mechanical Engineering, University of Washington, Seattle, WA, U.S.A.
⁶ Department of Bioengineering, University of Washington, Seattle, WA, U.S.A.
⁷ Department of Pathology, University of Washington, Seattle, WA, U.S.A.
⁸ Department of Radiology, Stanford University School of Medicine, Stanford, CA, U.S.A.

PMID: 33593036
DOI: 10.1002/lary.28822

Abstract

The rate of positive margins in head and neck cancers has remained stagnant over the past three decades and is consistently associated with poor overall survival. This suggests that significant improvements must be made intraoperatively to ensure negative margins. We discuss the important role of fluorescence imaging to guide surgical oncology in head and neck cancer. This review includes a general overview of the principles of fluorescence, available fluorophores used for fluorescence imaging, and specific clinical applications of fluorescence-guided surgery, as well as challenges and future directions in head and neck surgical oncology. Laryngoscope, 131:529-534, 2021.

Keywords: Fluorescence-guided surgery, near-infrared imaging, sentinel margin.

Publication types

Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Review

MeSH terms

Fluorescence
Head and Neck Neoplasms / surgery*
Humans
Margins of Excision
Optical Imaging / methods*
Squamous Cell Carcinoma of Head and Neck / surgery*
Surgery, Computer-Assisted / methods*

Grants and funding

R01 CA190306/CA/NCI NIH HHS/United States