Pyroptotic macrophages stimulate the SARS-CoV-2-associated cytokine storm

Jinghe Zhang; Haibo Wu; XiaoHong Yao; Dingyu Zhang; Yonggang Zhou; Binqing Fu; Wei Wang; Heng Li; Zhe Wang; Ziming Hu; Yong Ren; Rui Sun; Zhigang Tian; Xiuwu Bian; Haiming Wei

doi:10.1038/s41423-021-00665-0

Pyroptotic macrophages stimulate the SARS-CoV-2-associated cytokine storm

Cell Mol Immunol. 2021 May;18(5):1305-1307. doi: 10.1038/s41423-021-00665-0. Epub 2021 Mar 19.

Authors

Jinghe Zhang^#^{1

2}, Haibo Wu^#^{1

3}, XiaoHong Yao⁴, Dingyu Zhang⁵, Yonggang Zhou^{1

2}, Binqing Fu^{1

2}, Wei Wang^{1

3}, Heng Li^{1

3}, Zhe Wang^{1

3}, Ziming Hu^{1

2}, Yong Ren⁶, Rui Sun^{1

2}, Zhigang Tian^{7

8}, Xiuwu Bian⁹, Haiming Wei^{10

11}

Affiliations

¹ Department of Pathology, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, Anhui, China.
² Institute of Immunology and the CAS Key Laboratory of Innate Immunity and Chronic Disease, School of Life Science and Medical Center, University of Science and Technology of China, Hefei, Anhui, China.
³ Intelligent Pathology Institute, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, Anhui, China.
⁴ Institute of Pathology, Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing, China.
⁵ Wuhan Jinyintan Hospital (Wuhan Hospital for Infectious Diseases), Wuhan, Hubei, China.
⁶ General Hospital of Central Theater Command, PLA, Wuhan, China.
⁷ Department of Pathology, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, Anhui, China. tzg@ustc.edu.cn.
⁸ Institute of Immunology and the CAS Key Laboratory of Innate Immunity and Chronic Disease, School of Life Science and Medical Center, University of Science and Technology of China, Hefei, Anhui, China. tzg@ustc.edu.cn.
⁹ Institute of Pathology, Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing, China. bianxiuwu@263.net.
¹⁰ Department of Pathology, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, Anhui, China. ustcwhm@ustc.edu.cn.
¹¹ Institute of Immunology and the CAS Key Laboratory of Innate Immunity and Chronic Disease, School of Life Science and Medical Center, University of Science and Technology of China, Hefei, Anhui, China. ustcwhm@ustc.edu.cn.

^# Contributed equally.

No abstract available

Publication types

Letter
Research Support, Non-U.S. Gov't

MeSH terms

Aged
Aged, 80 and over
Autopsy
COVID-19 / immunology*
COVID-19 / metabolism
COVID-19 / pathology
COVID-19 / virology
Case-Control Studies
Cytokine Release Syndrome / immunology*
Cytokine Release Syndrome / metabolism
Cytokine Release Syndrome / pathology
Cytokine Release Syndrome / virology
Cytokines / immunology*
Cytokines / metabolism
Female
Host-Pathogen Interactions
Humans
Macrophage Activation*
Macrophages / immunology*
Macrophages / metabolism
Macrophages / pathology
Macrophages / virology
Male
Middle Aged
Phenotype
Pyroptosis*
SARS-CoV-2 / immunology*
SARS-CoV-2 / pathogenicity
Severity of Illness Index
THP-1 Cells

Substances

Cytokines