Do arachnoid cysts grow? A retrospective volumetric study

J Neurol. 2021 Oct;268(10):3777-3780. doi: 10.1007/s00415-021-10440-w. Epub 2021 Mar 27.

Abstract

Objective: Arachnoid cysts (ACs) are frequent incidental findings and may be associated with neuropsychiatric symptoms. Usually growth of the ACs with pressure on adjacent brain tissue is regarded as cause of the symptoms. This study was undertaken to identify if and which ACs grow with time.

Methods: We used a large database of cranial MRIs for a retrospective analysis.

Results: During a period of 10 years, we collected 166 ACs of 50 persons, mean observational period was 2.5 years. Among these, only larger cysts at the temporal pole, i.e., Galassi II ACs, grew with a rate of 0.3 ml a year (β = 0.32, SE 0.07, p = 0.003); all other ACs remained constant in size or became smaller. All cysts were clinically silent.

Conclusions: Most ACs remain constant in size or become smaller.

Classification of evidence: This study provides Class III evidence that the majority of arachnoid cysts does not grow.

Keywords: Arachnoid cyst; Incidental finding; Middle cranial fossa; Temporal lobe.

MeSH terms

  • Arachnoid Cysts* / complications
  • Arachnoid Cysts* / diagnostic imaging
  • Brain
  • Humans
  • Magnetic Resonance Imaging
  • Retrospective Studies
  • Temporal Lobe