Superparamagnetic iron oxide-gold nanoparticles conjugated with porous coordination cages: Towards controlled drug release for non-invasive neuroregeneration

Muzhaozi Yuan; Tian-Hao Yan; Jialuo Li; Zhifeng Xiao; Yu Fang; Ya Wang; Hong-Cai Zhou; Jean-Philippe Pellois

doi:10.1016/j.nano.2021.102392

Superparamagnetic iron oxide-gold nanoparticles conjugated with porous coordination cages: Towards controlled drug release for non-invasive neuroregeneration

Nanomedicine. 2021 Jul:35:102392. doi: 10.1016/j.nano.2021.102392. Epub 2021 Apr 16.

Authors

Muzhaozi Yuan¹, Tian-Hao Yan², Jialuo Li³, Zhifeng Xiao⁴, Yu Fang⁵, Ya Wang⁶, Hong-Cai Zhou⁷, Jean-Philippe Pellois⁸

Affiliations

¹ J. Mike Walker '66 Department of Mechanical Engineering, Texas A&M University, College Station, TX, USA. Electronic address: muzhaozi.yuan@tamu.edu.
² Department of Chemistry, Texas A&M University, College Station, TX, USA. Electronic address: thyan426@tamu.edu.
³ Department of Chemistry, Texas A&M University, College Station, TX, USA. Electronic address: lijialuo@tamu.edu.
⁴ Department of Chemistry, Texas A&M University, College Station, TX, USA. Electronic address: xiao@tamu.edu.
⁵ State Key Laboratory for Chemo/Bio-Sensing and Chemometrics, College of Chemistry and Chemical Engineering, Hunan University, Changsha, Hunan, P. R. China. Electronic address: yu.fang@hnu.edu.cn.
⁶ J. Mike Walker '66 Department of Mechanical Engineering, Texas A&M University, College Station, TX, USA; Department of Electrical and Computer Engineering, Texas A&M University, College Station, TX, USA; Department of Biomedical Engineering, Texas A&M University, College Station, TX, USA. Electronic address: ya.wang@tamu.edu.
⁷ Department of Chemistry, Texas A&M University, College Station, TX, USA. Electronic address: zhou@chem.tamu.edu.
⁸ Department of Chemistry, Texas A&M University, College Station, TX, USA; Department of Biochemistry and Biophysics, Texas A&M University, College Station, TX, USA. Electronic address: pellois@tamu.edu.

Abstract

This paper reports a smart intracellular nanocarrier for sustainable and controlled drug release in non-invasive neuroregeneration. The nanocarrier is composed by superparamagnetic iron oxide-gold (SPIO-Au) core-shell nanoparticles (NPs) conjugated with porous coordination cages (PCCs) through the thiol-containing molecules as bridges. The negatively charged PCC-2 and positively charged PCC-3 are compared for intracellular targeting. Both types result in intracellular targeting via direct penetration across cellular membranes. However, the pyrene (Py)-PEG-SH bridge enabled functionalization of SPIO-Au NPs with PCC-3 exhibits higher interaction with PC-12 neuron-like cells, compared with the rhodamine B (RhB)-PEG-SH bridge enabled case and the stand-alone SPIO-Au NPs. With neglectable toxicities to PC-12 cells, the proposed SPIO-Au-RhB(Py)-PCC-2(3) nanocarriers exhibit effective drug loading capacity of retinoic acid (RA) at 13.505 μg/mg of RA/NPs within 24 h. A controlled release of RA is achieved by using a low-intensity 525 nm LED light (100% compared to 40% for control group within 96 h).

Keywords: Intracellular targeting; Non-invasive neuroregeneration; Porous coordination cages; Superparamagnetic iron oxide-gold nanoparticles; Sustainable and controlled drug release.

Publication types

Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

Animals
Delayed-Action Preparations / chemistry
Delayed-Action Preparations / pharmacokinetics
Delayed-Action Preparations / pharmacology
Drug Carriers* / chemistry
Drug Carriers* / pharmacokinetics
Drug Carriers* / pharmacology
Ferric Compounds* / chemistry
Ferric Compounds* / pharmacokinetics
Ferric Compounds* / pharmacology
Gold* / chemistry
Gold* / pharmacokinetics
Gold* / pharmacology
Nanoparticles* / chemistry
Nanoparticles* / therapeutic use
Nerve Regeneration / drug effects*
PC12 Cells
Porosity
Rats
Tretinoin* / chemistry
Tretinoin* / pharmacokinetics
Tretinoin* / pharmacology

Substances

Delayed-Action Preparations
Drug Carriers
Ferric Compounds
ferric oxide
Tretinoin
Gold

Grants and funding

R01 GM110137/GM/NIGMS NIH HHS/United States