Modeling the evolution of COVID-19 via compartmental and particle-based approaches: Application to the Cyprus case

PLoS One. 2021 May 6;16(5):e0250709. doi: 10.1371/journal.pone.0250709. eCollection 2021.

Abstract

We present two different approaches for modeling the spread of the COVID-19 pandemic. Both approaches are based on the population classes susceptible, exposed, infectious, quarantined, and recovered and allow for an arbitrary number of subgroups with different infection rates and different levels of testing. The first model is derived from a set of ordinary differential equations that incorporates the rates at which population transitions take place among classes. The other is a particle model, which is a specific case of crowd simulation model, in which the disease is transmitted through particle collisions and infection rates are varied by adjusting the particle velocities. The parameters of these two models are tuned using information on COVID-19 from the literature and country-specific data, including the effect of restrictions as they were imposed and lifted. We demonstrate the applicability of both models using data from Cyprus, for which we find that both models yield very similar results, giving confidence in the predictions.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Algorithms
  • COVID-19 / diagnosis
  • COVID-19 / epidemiology*
  • Computer Simulation
  • Cyprus / epidemiology
  • Epidemiological Monitoring
  • Humans
  • Models, Statistical
  • Quarantine
  • SARS-CoV-2 / isolation & purification

Grants and funding

AI is supported by the project "Modeling of the COVID-19 pandemic for Cyprus", contract number CONCEPT-COVID/0420/0011, funded by the Cyprus Research and Innovation Foundation: https://www.research.org.cy VH and NS are supported by project "SimEA", funded by the European Union’s Horizon 2020 research and innovation programme under grant agreement No 810660: https://ec.europa.eu/programmes/horizon2020/en The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.