BNT162b2 Messenger RNA Vaccination Did Not Prevent an Outbreak of Severe Acute Respiratory Syndrome Coronavirus 2 Variant 501Y.V2 in an Elderly Nursing Home but Reduced Transmission and Disease Severity

Benoit Bailly; Luc Guilpain; Kevin Bouiller; Catherine Chirouze; Melissa N'Debi; Alexandre Soulier; Vanessa Demontant; Jean-Michel Pawlotsky; Christophe Rodriguez; Slim Fourati

doi:10.1093/cid/ciab446

BNT162b2 Messenger RNA Vaccination Did Not Prevent an Outbreak of Severe Acute Respiratory Syndrome Coronavirus 2 Variant 501Y.V2 in an Elderly Nursing Home but Reduced Transmission and Disease Severity

Clin Infect Dis. 2022 Feb 11;74(3):517-520. doi: 10.1093/cid/ciab446.

Authors

Benoit Bailly^{1

2}, Luc Guilpain³, Kevin Bouiller^{2

4}, Catherine Chirouze^{2

4}, Melissa N'Debi⁵, Alexandre Soulier⁶, Vanessa Demontant⁵, Jean-Michel Pawlotsky^{6

7}, Christophe Rodriguez^{5

6

7}, Slim Fourati^{6

7}

Affiliations

¹ Department of Infectious Disease, University Hospital of Besançon, Besançon, France.
² Department of Infectious Disease, Hospital of Lons Le Saunier, Lons Le Saunier, France.
³ Department of Medical Laboratory, Hospital of Lons Le Saunier, Lons Le Saunier, France.
⁴ UMR-CNRS 6249 Chrono-environnement, Université Bourgogne Franche-Comté, Besançon, France.
⁵ Genomics Platform, Hôpital Henri Mondor (AP-HP), Université Paris-Est, Créteil, France.
⁶ Virology Unit, Department of Prevention, Diagnosis and Treatment of Infections, Hôpital Henri Mondor (AP-HP), Université Paris-Est, Créteil, France.
⁷ Institut Mondor de Recherche Biomédicale, INSERM U955, Université Paris-Est, Créteil, France.

Abstract

We report an outbreak of severe acute respiratory syndrome coronavirus 2 501Y.V2 in a nursing home. All nonvaccinated residents (5/5) versus half of those vaccinated with BNT162b2 (13/26) were infected. Two of 13 vaccinated versus 4 of 5 nonvaccinated residents presented severe disease. BNT162b2 did not prevent the outbreak, but reduced transmission and disease severity.

Keywords: BNT162b2 vaccine; SARS CoV-2; nursing home; outbreak; variant.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Aged
BNT162 Vaccine
COVID-19*
Disease Outbreaks
Humans
Nursing Homes
RNA, Messenger
SARS-CoV-2*
Severity of Illness Index
Vaccination

Substances

RNA, Messenger
BNT162 Vaccine

Supplementary concepts

SARS-CoV-2 variants

Grants and funding

Ministry of Health