Pan-HDAC (Histone Deacetylase) Inhibitors Increase Susceptibility of Thoracic Aortic Aneurysm and Dissection in Mice

Shumin Zhang; Zhujiang Liu; Nan Xie; Chuanbo Huang; Zhiqing Li; Fang Yu; Yi Fu; Qinghua Cui; Wei Kong

doi:10.1161/ATVBAHA.121.316808

Pan-HDAC (Histone Deacetylase) Inhibitors Increase Susceptibility of Thoracic Aortic Aneurysm and Dissection in Mice

Arterioscler Thromb Vasc Biol. 2021 Nov;41(11):2848-2850. doi: 10.1161/ATVBAHA.121.316808. Epub 2021 Sep 16.

Authors

Shumin Zhang^#^{1

2}, Zhujiang Liu^#^{1

2}, Nan Xie^#^{1

2}, Chuanbo Huang^{3

2}, Zhiqing Li^{1

2}, Fang Yu^{1

2}, Yi Fu^{1

2}, Qinghua Cui^{3

2}, Wei Kong^{1

2}

Affiliations

¹ Department of Physiology and Pathophysiology (S.Z., Z. Liu, N.X., Z. Li, F.Y., Y.F., W.K.), School of Basic Medical Sciences, Peking University, Beijing, China.
² Key Laboratory of Molecular Cardiovascular Sciences, Ministry of Education, Beijing, China (S.Z., Z. Liu, N.X., Z. Li, F.Y., Y.F., W.K., C.H., Q.C.).
³ Department of Biomedical Informatics, Department of Physiology and Pathophysiology, Center for Noncoding RNA Medicine (C.H., Q.C.), School of Basic Medical Sciences, Peking University, Beijing, China.

^# Contributed equally.

No abstract available

Keywords: aortic dissection; histone deacetylase inhibitors; thoracic aortic aneurysm.

Publication types

Letter
Research Support, Non-U.S. Gov't

MeSH terms

Aminopropionitrile / analogs & derivatives
Animals
Aorta, Thoracic / drug effects*
Aorta, Thoracic / enzymology
Aorta, Thoracic / pathology
Aortic Aneurysm, Thoracic / chemically induced*
Aortic Aneurysm, Thoracic / enzymology
Aortic Aneurysm, Thoracic / pathology
Aortic Dissection / chemically induced*
Aortic Dissection / enzymology
Aortic Dissection / pathology
Cefixime / toxicity
Disease Models, Animal
Fluoroquinolones / toxicity
Histone Deacetylase Inhibitors / toxicity*
Male
Mice
Mice, Inbred C57BL
Panobinostat / toxicity
Risk Assessment
Risk Factors
Severity of Illness Index

Substances

Fluoroquinolones
Histone Deacetylase Inhibitors
beta-aminopropionitrile fumarate
Aminopropionitrile
Panobinostat
Cefixime