Cisplatin combined with capecitabine-induced chemotherapy for local nasopharyngeal carcinoma can improve the quality of life and reduce toxic and side effects

World J Surg Oncol. 2021 Sep 17;19(1):280. doi: 10.1186/s12957-021-02393-1.

Abstract

Background: This study was designed to probe into the effect of cisplatin combined with capecitabine on nasopharyngeal carcinoma (NPC).

Methods: A total of 136 NPC patients treated for the first time in our hospital from January 2016 to March 2017 were collected and divided into two groups: A and B. Among them, 66 in group A were treated with cisplatin intravenous drip, while 70 in group B were treated with capecitabine on the basis of group A. The efficacy, toxic and side effects, and quality of life of the two groups were observed.

Results: The short-term efficacy of group B was better than that of group A (p<0.05). The toxic and side effects of group B were lower than that of group A (p<0.05). The quality of life in group B was higher than that in group A (p<0.05).

Conclusions: Cisplatin combined with capecitabine-induced chemotherapy for local NPC can improve the quality of life and reduce the toxic and side effects.

Keywords: Capecitabine; Cisplatin; Nasopharyngeal carcinoma; Toxic and side effects.

MeSH terms

  • Antineoplastic Combined Chemotherapy Protocols / adverse effects
  • Capecitabine / adverse effects
  • Chemoradiotherapy
  • Cisplatin* / adverse effects
  • Fluorouracil / adverse effects
  • Humans
  • Nasopharyngeal Carcinoma / drug therapy
  • Nasopharyngeal Neoplasms* / drug therapy
  • Prognosis
  • Quality of Life

Substances

  • Capecitabine
  • Cisplatin
  • Fluorouracil