The association of maternal obesity and race with serum adipokines in pregnancy and postpartum: Implications for gestational weight gain and infant birth weight

Adam Jara; Mary Dreher; Kyle Porter; Lisa M Christian

doi:10.1016/j.bbih.2020.100053

The association of maternal obesity and race with serum adipokines in pregnancy and postpartum: Implications for gestational weight gain and infant birth weight

Brain Behav Immun Health. 2020 Feb 26:3:100053. doi: 10.1016/j.bbih.2020.100053. eCollection 2020 Mar.

Authors

Adam Jara¹, Mary Dreher², Kyle Porter³, Lisa M Christian^{1

2

4

5}

Affiliations

¹ Department of Psychiatry & Behavioral Health, The Ohio State University Medical Center, Columbus, OH, USA.
² The Institute for Behavioral Medicine Research, The Ohio State University Medical Center, Columbus, OH, USA.
³ Center for Biostatistics, The Ohio State University Medical Center, Columbus, OH, USA.
⁴ Department of Obstetrics and Gynecology, The Ohio State University Medical Center, Columbus, OH, USA.
⁵ Department of Psychology, The Ohio State University Medical Center, Columbus, OH, USA.

Abstract

Adiponectin and leptin are hormones known to play roles in maternal metabolism during pregnancy. Levels of these hormones have been demonstrated to vary based on adiposity and race. However, there is a lack of data concerning the relationship between race and the change of adiponectin and leptin throughout pregnancy. The purpose of this study was to examine serum levels of adiponectin, leptin, and leptin-to-adiponectin ratio (LAR) throughout pregnancy and to assess their association with gestational weight gain (GWG) and infant birth weight while considering the effects of race and pre-pregnancy body mass index (BMI). Serum levels of adiponectin, leptin, gestational weight gain, and infant birth weight were measured in 80 pregnant women at early (12.4 ± 1.3 weeks gestation), mid (20.6 ± 1.3 weeks gestation), late pregnancy (29.2 ± 1.4 weeks gestation), and 7-11 weeks postpartum (8.8 ± 0.8 weeks). In women overall, serum adiponectin decreased across pregnancy and increased at postpartum (p = 0.17.) At each prenatal timepoint, both black race and obesity were associated with lower adiponectin (ps < 0.05). In women overall, serum leptin increased across pregnancy, and declined at postpartum. At every assessment, a stepwise increase in leptin was observed in relation to BMI class. Black women with obesity had markedly higher LAR in mid- and late pregnancy and postpartum than all other groups (p < 0.05). Serum leptin during pregnancy was significantly associated with total GWG in both black and white women (ps < 0.005). Neither adiponectin, leptin, nor LAR were associated with infant birth weight. Race and BMI both have significant effects on serum adiponectin, leptin, and LAR levels in pregnancy and postpartum. Notably, the combined effects of race and BMI result in markedly higher LAR among black women with obesity. Implications for racial disparities in metabolic syndrome and postpartum weight retention remain to be explicated.

Keywords: Adiponectin; Gestational weight gain; Infant birth weight; Leptin; Leptin-adiponectin ratio; Race.