Antifungal drug resistance: Deciphering the mechanisms governing multidrug resistance in the fungal pathogen Candida glabrata

Nicole Robbins; Leah E Cowen

doi:10.1016/j.cub.2021.09.071

Antifungal drug resistance: Deciphering the mechanisms governing multidrug resistance in the fungal pathogen Candida glabrata

Curr Biol. 2021 Dec 6;31(23):R1520-R1523. doi: 10.1016/j.cub.2021.09.071.

Authors

Nicole Robbins¹, Leah E Cowen²

Affiliations

¹ Department of Molecular Genetics, University of Toronto, Toronto, Ontario M5G 1M1, Canada.
² Department of Molecular Genetics, University of Toronto, Toronto, Ontario M5G 1M1, Canada. Electronic address: leah.cowen@utoronto.ca.

PMID: 34875240
DOI: 10.1016/j.cub.2021.09.071

Abstract

Fungal infections pose a significant health burden. In a new study, Candida glabrata isolates resistant to mechanistically distinct antifungals were evolved, unveiling mutations in ERG3 as a novel mechanism by which this pathogen evolves multidrug resistance.

Publication types

Comment

MeSH terms

Antifungal Agents / pharmacology
Candida glabrata* / genetics
Drug Resistance, Fungal* / drug effects
Drug Resistance, Fungal* / genetics
Drug Resistance, Multiple / drug effects
Microbial Sensitivity Tests

Substances

Antifungal Agents