A binding-enhanced but enzymatic activity-eliminated human ACE2 efficiently neutralizes SARS-CoV-2 variants

Signal Transduct Target Ther. 2022 Jan 11;7(1):10. doi: 10.1038/s41392-021-00821-y.

Anqi Zheng^#^{1

2}, Lili Wu^#¹, Renyi Ma^#¹, Pu Han^#¹, Baoying Huang³, Chengpeng Qiao¹, Qihui Wang⁴, Wenjie Tan⁵, George F Gao⁶, Pengcheng Han^{7

8}

¹ CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, 100101, China.
² University of the Chinese Academy of Sciences, Beijing, 100049, China.
³ National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention (China CDC), Beijing, 102206, China.
⁴ CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, 100101, China. wangqihui@im.ac.cn.
⁵ National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention (China CDC), Beijing, 102206, China. tanwj@ivdc.chinacdc.cn.
⁶ CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, 100101, China. gaof@im.ac.cn.
⁷ CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, 100101, China. pengchenghan85@163.com.
⁸ School of Medicine, Zhongda Hospital, Southeast University, NanJing, 210009, China. pengchenghan85@163.com.

^# Contributed equally.

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