Potential Role of SUMO and SUMOylation in the Pathogenesis of Diabetes Mellitus

Mahvash Sadeghi; Sajad Dehnavi; Mojtaba Shohan; Tannaz Jamialahmadi; Thozhukat Sathyapalan; Amirhossein Sahebkar

doi:10.2174/0929867329666220817142848

Potential Role of SUMO and SUMOylation in the Pathogenesis of Diabetes Mellitus

Curr Med Chem. 2023;30(14):1623-1637. doi: 10.2174/0929867329666220817142848.

Authors

Mahvash Sadeghi^{1

2}, Sajad Dehnavi^{1

2}, Mojtaba Shohan^{1

2}, Tannaz Jamialahmadi^{3

4}, Thozhukat Sathyapalan⁵, Amirhossein Sahebkar^{3

6

7

8}

Affiliations

¹ Department of Immunology, Faculty of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
² Student Research Committee, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
³ Applied Biomedical Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
⁴ Surgical Oncology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
⁵ Department of Academic Diabetes, Endocrinology and Metabolism, Hull York Medical School, University of Hull, Hull HU3 2JZ, UK.
⁶ Biotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran.
⁷ School of Medicine, The University of Western Australia, Perth, Australia.
⁸ Department of Biotechnology, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran.

PMID: 35980066
DOI: 10.2174/0929867329666220817142848

Abstract

Diabetes mellitus is a group of metabolic disorders characterized by hyperglycemia and associated with multiple organ systems complications. The incidence and prevalence of diabetes are increasing in an epidemic proportion worldwide. In addition to environmental factors, some epigenetic and post-translational modifications have critical roles in the pathogenesis of diabetes and its complications. Reversible covalent modification such as SUMOylation by SUMO (Small Ubiquitin-like Modifier) has emerged as a new mechanism that affects the dynamic regulation of proteins. In this review, we initially focus on the function of SUMO and SUMOylation. Subsequently, we assess the potential effects of this process in the pathogenesis of type 1 and 2 diabetes mellitus.

Keywords: Diabetes mellitus; SUMO; SUMOylation; Small Ubiquitin-like modifier; epigenetic; hyperglycemia.

Publication types

Review

MeSH terms

Diabetes Mellitus, Type 1*
Diabetes Mellitus, Type 2*
Humans
Protein Processing, Post-Translational
Small Ubiquitin-Related Modifier Proteins / genetics
Small Ubiquitin-Related Modifier Proteins / metabolism
Sumoylation

Substances

Small Ubiquitin-Related Modifier Proteins