Abstract
From the culture broth of Streptomyces nodosus MH190-16F3, four new antibiotics have been isolated, and named saquayamycins A, B, C and D. The compounds are glycosides of aquayamycin, and among aquayamycin-group antibiotics they are most closely related to P-1894B (vineomycin A1). All saquayamycins act on Gram-positive bacteria and inhibit the growth of adriamycin-sensitive and adriamycin-resistant P388 leukemia cells.
Publication types
-
Research Support, Non-U.S. Gov't
-
Research Support, U.S. Gov't, P.H.S.
MeSH terms
-
Animals
-
Anthraquinones / isolation & purification*
-
Antibiotics, Antineoplastic / isolation & purification*
-
Antibiotics, Antineoplastic / pharmacology
-
Bacteria / drug effects
-
Chemical Phenomena
-
Chemistry
-
Fermentation
-
Leukemia P388 / drug therapy
-
Streptomyces / metabolism*
Substances
-
Anthraquinones
-
Antibiotics, Antineoplastic
-
saquayamycin
-
saquayamycin B
-
saquayamycin C
-
saquayamycin D