The RBE for mouse bladders after irradiation with 1 to 8 fractions of d(4)+ Be neutrons

Br J Radiol. 1986 Jan;59(697):61-8. doi: 10.1259/0007-1285-59-697-61.

Abstract

Mouse bladders were irradiated with 1,2,4 or 8 fractions of electrons or neutrons. Urination frequency was scored from 9 to 14 months after irradiation and this was used as a measure of the extent of bladder damage. The RBE for neutrons relative to 1.8 MeV electrons increased from 3.2 for large single doses to 5.4 for 8 fractions. Repair of sublethal injury after electron irradiation was considerable, with 63-72% of each fractionated dose repaired. Repair after neutron irradiation was less, with only 35-43% of each fractionated dose recovered. Linear-quadratic analysis of all the fractionated bladder data yielded an alpha/beta ratio for electrons of 6-7 Gy and, surprisingly, the alpha/beta ratio for neutrons was only slightly higher at about 8 Gy.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Dose-Response Relationship, Radiation
  • Electrons
  • Female
  • Mice
  • Mice, Inbred CBA
  • Neutrons
  • Radiation Injuries, Experimental*
  • Relative Biological Effectiveness
  • Urinary Bladder / radiation effects*
  • Urination / radiation effects