Abstract
A rabbit hepatic protein that specifically binds asialoglycoproteins is also a lectin that agglutinates untreated human and rabbit erythrocytes and neuraminidase-treated erythrocytes from rat, mouse, and guinea pig. Both binding of asialoglycoproteins and agglutination of erythrocytes appear to involve reaction on the same active sites of the hepatic protein.
MeSH terms
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Agglutination / drug effects
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Agglutinins / metabolism*
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Animals
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Binding Sites
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Chromatography, Affinity
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Erythrocytes / cytology
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Erythrocytes / drug effects
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Erythrocytes / metabolism
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Glycoproteins / metabolism*
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Guinea Pigs
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Humans
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Isoantigens / metabolism
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Liver / metabolism*
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Mice
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Neuraminidase / metabolism
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Protein Binding / drug effects
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Rabbits
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Rats
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Sialic Acids / metabolism
Substances
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Agglutinins
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Glycoproteins
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Isoantigens
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Sialic Acids
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Neuraminidase