Abstract
A series of 5-aryl-2H-tetrazoles, 5-aryl-2H-tetrazole-2-acetic acids, and [(4-phenyl-5-aryl-4H-1,2,4-triazol-3-yl)thio]acetic acids were synthesized and tested in vitro for superoxide scavenging activity, in vivo in the carrageenan-induced rat paw edema assay, and in the reverse passive Arthus reaction. The hydroxy-substituted compounds were effective as in vitro scavengers of superoxide but were not effective as in vivo antiinflammatory agents.
Publication types
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Comparative Study
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Research Support, Non-U.S. Gov't
MeSH terms
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Acetates / chemical synthesis*
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Acetates / pharmacology
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Animals
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Anti-Inflammatory Agents / chemical synthesis*
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Arthus Reaction
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Azoles / chemical synthesis*
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Biological Assay
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Edema / drug therapy
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Indicators and Reagents
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Magnetic Resonance Spectroscopy
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Rats
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Spectrophotometry, Infrared
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Structure-Activity Relationship
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Superoxides / metabolism*
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Tetrazoles / chemical synthesis*
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Tetrazoles / pharmacology
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Triazoles / chemical synthesis*
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Triazoles / pharmacology
Substances
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Acetates
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Anti-Inflammatory Agents
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Azoles
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Indicators and Reagents
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Tetrazoles
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Triazoles
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Superoxides