Abstract
This paper deals with three themes: (1) the nature of differentiation in normal and leukemic processes, (2) stochastic and deterministic control mechanisms that affect differentiation, and (3) the nature of the events that separate self-renewing stem cells from their committed descendants. These all impinge on both myelopoietic and lymphopoietic leukemias. The view is advanced that differentiation continues in these diseases, but new programs are assembled abnormally but with normal components.
Publication types
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Comparative Study
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Research Support, Non-U.S. Gov't
MeSH terms
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B-Lymphocytes
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Cell Differentiation*
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Cell Division
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Cell Line
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Clone Cells
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Colony-Forming Units Assay
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Doxorubicin / therapeutic use
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Genes, MHC Class II
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Glucosephosphate Dehydrogenase / genetics
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Granulocytes
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Hematopoiesis*
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Hematopoietic Stem Cells / physiology*
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Humans
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Leukemia / blood*
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Leukemia, Myeloid, Acute / blood
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Leukemia, Myeloid, Acute / drug therapy
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Prognosis
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T-Lymphocytes
Substances
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Doxorubicin
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Glucosephosphate Dehydrogenase