Abstract
In mature male rats both estradiol administration as well as castration had a striking suppressive effect on the hepatic activity of the microsomal ethanol-oxidizing system, whereas alcohol dehydrogenase activity was increased under these experimental conditions. The castration effects on the activities of the alcohol-metabolizing enzymes could be completely prevented by the administration of testosterone. Therefore, these results indicate the sex-dependent nature of the hepatic microsomal ethanol-oxidizing system and alcohol dehydrogenase.
MeSH terms
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Alcohol Dehydrogenase
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Alcohol Oxidoreductases / metabolism
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Animals
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Castration
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Catalase / metabolism
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Cytochrome P-450 Enzyme System / metabolism
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Estradiol / pharmacology
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Ethanol / metabolism*
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Gonadal Steroid Hormones / pharmacology*
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Liver / enzymology*
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Male
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NADPH-Ferrihemoprotein Reductase / metabolism
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Rats
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Rats, Inbred Lew
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Subcellular Fractions / enzymology
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Testosterone / pharmacology
Substances
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Gonadal Steroid Hormones
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Ethanol
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Testosterone
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Estradiol
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Cytochrome P-450 Enzyme System
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Alcohol Oxidoreductases
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Alcohol Dehydrogenase
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Catalase
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NADPH-Ferrihemoprotein Reductase