Evidence for two species of insulin-like growth factor II (IGF II and "big" IGF II) in human spinal fluid

Endocrinology. 1982 May;110(5):1822-4. doi: 10.1210/endo-110-5-1822.

Abstract

Human serum contains the somatomedins, insulin-like growth factor I and II (IGF I and II). In spinal fluid, however, only IGF II was found in measurable and significant amounts. In addition, an IGF II of larger mass could be detected by a radioimmunoassay for IGF II. This "big" IGF II is biologically active and has an apparent molecular weight of 9000.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Humans
  • Insulin / blood
  • Insulin / cerebrospinal fluid*
  • Molecular Weight
  • Peptides / blood
  • Peptides / cerebrospinal fluid*
  • Radioimmunoassay
  • Reference Values
  • Somatomedins / blood
  • Somatomedins / cerebrospinal fluid*

Substances

  • Insulin
  • Peptides
  • Somatomedins