The novel desmethyldestruxin B2, from Metarhizium anisopliae, that suppresses hepatitis B virus surface antigen production in human hepatoma cells

H Chen; S F Yeh; G T Ong; S H Wu; C M Sun; C K Chou

doi:10.1021/np50118a007

The novel desmethyldestruxin B2, from Metarhizium anisopliae, that suppresses hepatitis B virus surface antigen production in human hepatoma cells

J Nat Prod. 1995 Apr;58(4):527-31. doi: 10.1021/np50118a007.

Authors

H Chen¹, S F Yeh, G T Ong, S H Wu, C M Sun, C K Chou

Affiliation

¹ Institute of Biochemistry, National Yang-Ming University, Taipei, Taiwan.

PMID: 7623030
DOI: 10.1021/np50118a007

Abstract

We have examined the antiviral activity of a crude extract prepared from the culture medium of the fungus Metarhizium anisopliae. Eight active destruxins were identified which showed strong suppressive effect on the production of the hepatitis B surface antigen (HBsAg) in human hepatoma Hep3B cells. One new compound, desmethyldestruxin B2 [1], was isolated from M. anisopliae. This structure was determined based on its nmr and mass spectral data.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Culture Media
Hepatitis B Surface Antigens / biosynthesis*
Humans
Liver Neoplasms, Experimental / metabolism*
Magnetic Resonance Spectroscopy
Mass Spectrometry
Mitosporic Fungi / chemistry*
Peptides, Cyclic / chemistry
Peptides, Cyclic / isolation & purification
Peptides, Cyclic / pharmacology*
Tumor Cells, Cultured

Substances

Culture Media
Hepatitis B Surface Antigens
Peptides, Cyclic
desmethyldestruxin B2