The role of the central nervous system in sudden cardiac death: heartbeat dynamics in conscious pigs during coronary occlusion, psychologic stress and intracerebral propranolol

Integr Physiol Behav Sci. 1994 Oct-Dec;29(4):355-61. doi: 10.1007/BF02691355.

Abstract

Electrocardiograms were recorded in conscious pigs during psychological stress (touching), left anterior descending coronary artery occlusion, intracerebral levopropranolol (0.05 mg/kg), and their respective controls. The R-R intervals were evaluated with both a deterministic measure (point correlation dimension) and a stochastic one (mean). Only the deterministic measure was sensitive to between-subject responses (P < .01), whereas both measures were sensitive to within-subject changes. The results are explained by a deterministic model of heartbeat generation.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Central Nervous System / physiopathology*
  • Coronary Vessels / physiopathology*
  • Death, Sudden, Cardiac / etiology*
  • Electrocardiography / drug effects
  • Heart Rate / physiology*
  • Injections, Intraventricular
  • Propranolol / administration & dosage
  • Propranolol / pharmacology*
  • Stress, Psychological / physiopathology*
  • Swine

Substances

  • Propranolol