Abstract
FR901228, a novel antitumor antibiotic, reversed the transformed morphology of the Ha-ras transformants, Ras-1 cells, and inhibited their growth. The reduction of c-myc expression was observed in FR901228-treated Ras-1 cells by RNA dot-blot hybridization. This reduction of c-myc expression and morphological reversion of the transformed cells to normal were correlated with growth inhibition (G0/G1 arrest in cell cycle).
MeSH terms
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3T3 Cells / drug effects
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3T3 Cells / physiology
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Animals
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Anti-Bacterial Agents / pharmacology*
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Antibiotics, Antineoplastic / pharmacology*
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Blotting, Northern
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Cell Cycle / drug effects
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Cell Division / drug effects
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Cell Line, Transformed
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Cell Nucleus / drug effects
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Cell Nucleus / metabolism
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Chromobacterium / metabolism*
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DNA, Neoplasm / biosynthesis
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Depsipeptides*
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Flow Cytometry
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Gene Expression / drug effects
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Genes, myc / drug effects
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Genes, ras / drug effects*
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Kinetics
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Macromolecular Substances
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Mice
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Peptides, Cyclic*
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Signal Transduction / drug effects
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Transfection
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Transformation, Genetic / drug effects*
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Urinary Bladder Neoplasms / genetics
Substances
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Anti-Bacterial Agents
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Antibiotics, Antineoplastic
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DNA, Neoplasm
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Depsipeptides
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Macromolecular Substances
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Peptides, Cyclic
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romidepsin