Surface electromyography (EMG) and statistical analysis techniques were applied to investigate the response of finger flexor muscles to hand-transmitted vibration in all the three orthogonal directions. The trends in measured data were examined to derive the influence of variations in the tool-related parameters. Single-factor and multi-factor statistical analyses were performed to establish the significance of influence of different individual and coupled power tool-related parameters. The analysis of variance (ANOVA) results indicated that the vibration direction, acceleration and grip force influence the EMG of finger flexor muscles in a significant manner (P < 0.001), while the effect of vibration frequency was observed to be insignificant (P > 0.9). The electrical activity measured under different vibratory test conditions was observed to be 1.5-6.0 times higher than that measured under the static loads. The increase in electrical activity of the finger flexor muscles with an increase in the grip force was observed to be most significant under static as well as dynamic loading conditions.