Onset and staging of DSM-IV alcohol dependence using mean age and survival-hazard methods

J Abnorm Psychol. 1995 May;104(2):346-54. doi: 10.1037//0021-843x.104.2.346.

Abstract

Orderly onset of psychiatric symptoms has implications for both case detection and the construct validity of the underlying illness. Mean age and survival-hazard techniques were used to study the onset of alcohol abuse and dependence (as defined in the 4th edition of the Diagnostic and Statistical Manual of Mental Disorders; American Psychiatric Association, 1994) in 369 clinical cases drawn from a heterogeneous regional sample. The methods provided a similar general pattern of symptom sequencing, though only survival-hazard analysis described a punctuated onset of alcoholism in 3 discrete stages: alcohol abuse, dependence, and accommodation to the illness. This model survived a rigorous program of tests for goodness of fit and described the majority of the sample, supporting the construct validity of both alcohol abuse as a discrete first illness phase and of dependence as a set of core constructs distinct from and succeeding abuse. The specific strengths of survival-hazard analysis as a research tool in illness staging research are discussed.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Adult
  • Age of Onset*
  • Alcoholism / diagnosis*
  • Female
  • Humans
  • Male
  • Middle Aged
  • Psychiatric Status Rating Scales*
  • Severity of Illness Index
  • Substance-Related Disorders*