Abstract
The role played in immune surveillance by gamma delta T cells residing in various epithelia has not been clear. It is shown here that activated gamma delta T cells obtained from skin and intestine express the epithelial cell mitogen keratinocyte growth factor (KGF). In contrast, intraepithelial alpha beta T cells, as well as all lymphoid alpha beta and gamma delta T cell populations tested, did not produce KGF or promote the growth of cultured epithelial cells. These results suggest that intraepithelial gamma delta T cells function in surveillance and in repair of damaged epithelial tissues.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Animals
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Base Sequence
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Cell Division
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Cell Line
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Cells, Cultured
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Cloning, Molecular
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Dendritic Cells / physiology*
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Epithelial Cells
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Fibroblast Growth Factor 10
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Fibroblast Growth Factor 7
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Fibroblast Growth Factors*
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Growth Substances / biosynthesis*
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Growth Substances / genetics
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Keratinocytes / cytology*
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Lymphocyte Activation
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Mice
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Molecular Sequence Data
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Receptors, Antigen, T-Cell, gamma-delta*
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T-Lymphocyte Subsets / immunology
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T-Lymphocyte Subsets / metabolism
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T-Lymphocyte Subsets / physiology*
Substances
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Fgf7 protein, mouse
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Fibroblast Growth Factor 10
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Growth Substances
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Receptors, Antigen, T-Cell, gamma-delta
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Fibroblast Growth Factor 7
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Fibroblast Growth Factors