Anticholestatic effect of picroliv, active hepatoprotective principle of Picrorhiza kurrooa, against carbon tetrachloride induced cholestasis

B Saraswat; P K Visen; G K Patnaik; B N Dhawan

Anticholestatic effect of picroliv, active hepatoprotective principle of Picrorhiza kurrooa, against carbon tetrachloride induced cholestasis

Indian J Exp Biol. 1993 Apr;31(4):316-8.

Authors

B Saraswat¹, P K Visen, G K Patnaik, B N Dhawan

Affiliation

¹ ICMR Centre for Advanced Pharmacological Research on Traditional Remedies, Division of Pharmacology, Lucknow, India.

PMID: 8359830

Abstract

Picroliv showed a dose (3-12 mg/kg, po for 7 days) dependent choleretic activity as evidenced by increase in bile flow and its contents (bile salts and bile acids). Significant anticholestatic activity was also observed against carbon tetrachloride induced cholestasis in conscious rat, anaesthetized guinea pig and cat. Picroliv was more active than the known hepatoprotective drug silymarin.

Publication types

Comparative Study

MeSH terms

Animals
Bile Acids and Salts / biosynthesis
Carbon Tetrachloride
Cats
Cholestasis / prevention & control*
Cinnamates / therapeutic use*
Dose-Response Relationship, Drug
Female
Glycosides / therapeutic use*
Guinea Pigs
Male
Plant Extracts / therapeutic use*
Rats
Silymarin / therapeutic use
Vanillic Acid / therapeutic use*

Substances

Bile Acids and Salts
Cinnamates
Glycosides
Plant Extracts
Silymarin
kutkin
Carbon Tetrachloride
Vanillic Acid