Antifungal macrocyclic polylactones from Penicillium verruculosum

J Breinholt; G W Jensen; R I Nielsen; C E Olsen; J C Frisvad

doi:10.7164/antibiotics.46.1101

Antifungal macrocyclic polylactones from Penicillium verruculosum

J Antibiot (Tokyo). 1993 Jul;46(7):1101-8. doi: 10.7164/antibiotics.46.1101.

Authors

J Breinholt¹, G W Jensen, R I Nielsen, C E Olsen, J C Frisvad

Affiliation

¹ Novo Nordisk A/S, Plant Protection Division, Bagsvaerd, Denmark.

PMID: 8360106
DOI: 10.7164/antibiotics.46.1101

Abstract

Three macrocyclic polylactones have been isolated from Penicillium verruculosum. Two were found to be novel and the third to be identical with NG-012(1). Their structures were elucidated by spectroscopic and chemical methods. A full assignment of 1H- and 13C-resonances in acetone-d6 are given for all three compounds. The compounds show antifungal activity.

MeSH terms

Animals
Antifungal Agents* / biosynthesis
Antifungal Agents* / chemistry
Antifungal Agents* / pharmacology
Drug Screening Assays, Antitumor
Lactones* / chemistry
Lactones* / isolation & purification
Lactones* / pharmacology
Magnetic Resonance Spectroscopy
Mice
Molecular Structure
Penicillium / classification
Penicillium / metabolism
Phenols* / chemistry
Phenols* / isolation & purification
Phenols* / pharmacology

Substances

Antifungal Agents
Lactones
Phenols
NG 011
BK223 C