Abstract
A new C31 lanostane-type triterpene, assigned the trivial name suberosol [1], has been isolated from Polyalthia suberosa as an anti-HIV principle. The structure has been characterized as 24-methylenelanost-7,9(11)-diene-3 beta, 15 alpha-diol (suberosol) [1], based on spectroscopic evidence. Compound 1 was found to show anti-HIV replication activity in H9 lymphocyte cells with an EC50 of 3 micrograms/ml.
Publication types
-
Research Support, U.S. Gov't, P.H.S.
MeSH terms
-
Antiviral Agents / chemistry
-
Antiviral Agents / isolation & purification
-
Antiviral Agents / pharmacology*
-
Cells, Cultured
-
HIV Core Protein p24 / immunology
-
HIV-1 / drug effects*
-
Humans
-
Lymphocytes / microbiology
-
Magnetic Resonance Spectroscopy
-
Plants, Medicinal / chemistry*
-
Steroids / chemistry
-
Steroids / isolation & purification
-
Steroids / pharmacology*
Substances
-
Antiviral Agents
-
HIV Core Protein p24
-
Steroids
-
suberosol