Abstract
The efficacy of locally implanted antibiotic-calcium hydroxyapatite ceramic composites was investigated for the treatment of experimentally produced, implant-related osteomyelitis in rats. High concentrations of antibiotics were detected at the site of infection and bacteria were eradicated without removal of the metal implants. Parenteral antibiotics and surgical debridement, alone or in combination with antibiotic-impregnated acrylic bone cement, all failed to eradicate the infections.
Publication types
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Comparative Study
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Ceramics
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Drug Carriers
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Durapatite
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Female
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Gentamicins / administration & dosage*
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Hydroxyapatites / administration & dosage*
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Injections, Intraperitoneal
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Microscopy, Electron, Scanning
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Osteomyelitis / drug therapy*
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Prosthesis-Related Infections / drug therapy*
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Rats
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Rats, Sprague-Dawley
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Staphylococcal Infections / drug therapy*
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Staphylococcus aureus / ultrastructure
Substances
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Drug Carriers
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Gentamicins
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Hydroxyapatites
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Durapatite