Molecular markers in chemoprevention of colon cancer. Inhibition of expression of ras-p21 and p53 by sulindac during azoxymethane-induced colon carcinogenesis

Ann N Y Acad Sci. 1995 Sep 30:768:205-9. doi: 10.1111/j.1749-6632.1995.tb12123.x.
No abstract available

MeSH terms

  • Animals
  • Anticarcinogenic Agents / pharmacology*
  • Azoxymethane
  • Biomarkers, Tumor / analysis*
  • Blotting, Western
  • Carcinogens
  • Colon
  • Colonic Neoplasms / chemically induced
  • Colonic Neoplasms / metabolism
  • Colonic Neoplasms / prevention & control*
  • Intestinal Mucosa / drug effects
  • Intestinal Mucosa / metabolism
  • Intestinal Mucosa / pathology
  • Male
  • Proto-Oncogene Proteins p21(ras) / analysis
  • Proto-Oncogene Proteins p21(ras) / biosynthesis*
  • Rats
  • Rats, Inbred F344
  • Sulindac / pharmacology*
  • Tumor Suppressor Protein p53 / analysis
  • Tumor Suppressor Protein p53 / biosynthesis*

Substances

  • Anticarcinogenic Agents
  • Biomarkers, Tumor
  • Carcinogens
  • Tumor Suppressor Protein p53
  • Sulindac
  • Proto-Oncogene Proteins p21(ras)
  • Azoxymethane