A novel chitinase inhibitor from a marine bacterium, Pseudomonas sp

H Izumida; N Imamura; H Sano

doi:10.7164/antibiotics.49.76

A novel chitinase inhibitor from a marine bacterium, Pseudomonas sp

J Antibiot (Tokyo). 1996 Jan;49(1):76-80. doi: 10.7164/antibiotics.49.76.

Authors

H Izumida¹, N Imamura, H Sano

Affiliation

¹ Marine Biotechnology Institute, Shimizu Laboratories, Shizuoka 424, Japan.

PMID: 8609091
DOI: 10.7164/antibiotics.49.76

Abstract

A new chitinase inhibitor, CI-4, was isolated from the culture broth of a marine bacterium Pseudomonas sp. IZ208. The structure of CI-4 was determined to be cyclo(L-Arg-D-Pro) by spectral studies and comparison with a synthetic sample. CI-4 showed inhibitory activity against chitinase.

MeSH terms

Chitinases / antagonists & inhibitors*
Enzyme Inhibitors / chemistry
Enzyme Inhibitors / isolation & purification*
Enzyme Inhibitors / pharmacology
Peptides, Cyclic / biosynthesis*
Peptides, Cyclic / chemistry
Peptides, Cyclic / pharmacology
Pseudomonas / classification
Pseudomonas / metabolism*
Water Microbiology*

Substances

Enzyme Inhibitors
Peptides, Cyclic
cyclo(Arg-Pro)
Chitinases